41,059 people died in motor vehicle crashes in 2007.  4,602 of them died in large truck crashes.

http://www.iihs.org/research/fatality_facts_2007/largetrucks.html 

Based on the number of large trucks on the road and on the amount they travel, large trucks (tractor-trailers, single-unit trucks, and some cargo vans weighing more than 10,000 pounds) account for more than their share of highway deaths. Large trucks have higher fatal crash rates per mile traveled than passenger vehicles, although a higher percentage of large truck travel occurs on interstates, the safest roads.

Most deaths in large truck crashes are passenger vehicle occupants rather than occupants of large trucks. The main problem is the vulnerability of people traveling in smaller vehicles.

Trucks often weigh 20-30 times as much as passenger cars, and are taller with greater ground clearance.

Truck braking capability can be a factor in truck crashes. Loaded tractor-trailers take 20-40 percent farther than cars to stop, and the discrepancy is greater when trailers are empty, on wet and slippery roads, or with poorly maintained brakes.1 Truck driver fatigue also is a known crash risk. Drivers of large trucks are allowed by federal hours-of-service regulations to drive up to 11 hours at a stretch and up to 77 hours over a 7-day period. Surveys indicate that many drivers violate the regulations and work longer than permitted. 

A total of 4,602 people died in large truck crashes in 2007. Sixteen percent of these deaths were truck occupants, 70 percent were occupants of cars and other passenger vehicles, and 12 percent were pedestrians, bicyclists, or motorcyclists. Large truck crash deaths have declined 30 percent overall since 1979, when they were at an all-time high. There has been a greater percentage decline among occupants of large trucks (46 percent) than among occupants of passenger vehicles (24 percent).

 

truck-stats.jpgOccupant deaths in two-vehicle crashes involving a large truck and a passenger vehicle, 2007

Occupant type                            Deaths              %
Passenger vehicle occupants      2,494                 97
Large truck occupants                     78                  3
All occupant deaths                    2,572               100

Large trucks accounted for 4 percent of registered vehicles and 7 percent of miles traveled in 2007.5 Eleven percent of motor vehicle crash deaths in 2007 occurred in large truck crashes.

Percentage of motor vehicle crash deaths occuring in large truck crashes and other crashes, 2007

Crash type                                 Deaths                 %
Large truck crashes                       4,602                11
Other crashes                             36,457                 89
All crashes                                 41,059                100

Semi rolls on Interstate 10, snarling rush-hour traffic